Anti-inflammatory and Analgesic Properties of Albizia altissima (Hook f.) Hutch Dandy leaves in mice

Abstract

Albizia altissima (Hook f.) is used in traditional system in the treatment of pain, rheumatism, inflammation, fever, arthritis and mental illness. The antinociceptive properties of the plant have not been explored; hence the present work was carried out to evaluate the anti-inflammation and analgesic properties of Albizia altissima in mice. The anti-inflammation and analgesic properties of Albizia altissima was investigated; using carrageenan-induced paw oedema, histamine-induced paw oedema, formalin test, tail immersion test and acetic acid-induced abdominal constriction test in mice. The results showed that the crude extract of Albizia altissima (100 – 400 mg/kg; p.o) dose independently produced anti-oedematogenic activity in both carrageenan and histamine-induced paw oedema in mice. In the acetic acid-induced writhing model, Albizia altissima produced a dose dependent analgesic effect characterized by reduction in the number of abdominal writhes when compared to control. The extract also produced analgesic effect by producing a dose dependent decrease in formalin-induced paw licking time in mice.
It was concluded that Albizia altissima possessed anti-inflammatory and analgesic properties.