Neurobehavioral and Anticonvulsant effects of ethanol extract of Albizia adianthifolia leaves in experimental animals

Abstract

Albizia adianthifolia (Mimosoideae) is a medicinal plant used in the management of infections, and central nervous system disorders. We evaluated neurobehavioral and anticonvulsant properties of the ethanol extract of Albizia adianthifolia leaves (EEAAL). Effects of EEAAL (2.5 - 20 mg/kg, i.p.) on novelty-induced behaviors were determined in mice using open-field and hole board tests. Anticonvulsant property of EEAAL (20 - 140 mg/kg, i.p.) was evaluated using pentylenetetrazole, picrotoxin and strychnine-induced convulsions assays. The extract was administered intraperitoneally. The LD50 of EEAAL was 282 mg/kg, i.p. The EEAAL (2.5 - 20 mg/kg) significantly inhibited rearing (105.4±9.5, 94.4±5.9, 67.2±7.4, 32.6±3.8) and grooming (48.0±3.6, 33.8±2.9, 25.4±1.6, 7.6±0.8) as compared with controls (171.2±14.0; 83.8±4.4). The EEAAL (5 - 20 mg/kg) significantly inhibited locomotor activity (48.4±5.3, 37.8±1.8, 13.0±2.7) compared with control (65.4± 3.6). EEAAL (2.5 - 20 mg/kg) significantly decreased exploration on hole-board (24.2±1.7, 21.6±2.1, 17.2±1.2, 9.8±1.9) compared with control (43.2±3.3).In PTZ-induced seizure, EEAAL (80 and 140 mg/kg) offered protection in 50% and 33.3% of the animals respectively. In strychnine and picrotoxin-induced convulsion, EEAAL (80 and 140 mg/kg) significantly delayed onset and latency to death compared with control respectively. EEAAL has sedative and anticonvulsant effects thus justify its use in the management of mental illness and neurological disorders.